Ronald J Hill Selected Research

RN486

1/2015	Structure-based drug design of RN486, a potent and selective Bruton's tyrosine kinase (BTK) inhibitor, for the treatment of rheumatoid arthritis.
4/2012	RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodents.

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Ronald J Hill Research Topics

Disease

3	Experimental Arthritis 01/2021 - 12/2008
3	Rheumatoid Arthritis 01/2015 - 12/2008
2	Pemphigus (Pemphigus Vulgaris) 10/2020 - 08/2020
2	Hypersensitivity (Allergy) 03/2015 - 04/2012
2	Inflammation (Inflammations) 04/2012 - 12/2008
1	Bronchiolitis Obliterans Syndrome 01/2023
1	Arthus Reaction 01/2021
1	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 01/2021
1	Nephritis 01/2021
1	Neoplasms (Cancer) 12/2017
1	Disease Progression 11/2015
1	Colitis 11/2015
1	T-Cell Prolymphocytic Leukemia (Leukemia, T Cell, Chronic) 03/2015
1	B-Cell Lymphoma (Lymphoma, B Cell) 08/2013
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 08/2013
1	Immune Complex Diseases (Immune Complex Disease) 04/2012
1	Arthritis (Polyarthritis) 04/2012
1	Pain (Aches) 12/2008
1	Autoimmune Diseases (Autoimmune Disease) 12/2008
1	Hyperalgesia 12/2008
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 12/2008
1	T-Cell Leukemia (Leukemia, T Cell) 01/2006
1	Obesity 09/2005
1	Body Weight (Weight, Body) 09/2005
1	Insulin Resistance 09/2005
1	Facies 01/2002

Drug/Important Bio-Agent (IBA)

5	Agammaglobulinaemia Tyrosine KinaseIBA 10/2020 - 04/2012
2	Phosphotransferases (Kinase)IBA 01/2023 - 12/2017
2	RN486IBA 01/2015 - 04/2012
1	AutoantibodiesIBA 01/2021
1	PRN1371IBA 12/2017
1	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 12/2017
1	PRN694IBA 11/2015
1	OxazoloneIBA 03/2015
1	Syk KinaseIBA 08/2013
1	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 08/2013
1	Monoclonal AntibodiesIBA 08/2013
1	B-Cell Antigen Receptors (B Cell Antigen Receptors)IBA 08/2013
1	Rituximab (Mabthera)FDA Link 08/2013
1	Methotrexate (Mexate)FDA LinkGeneric 04/2012
1	pamapimodIBA 12/2008
1	Protein Kinases (Protein Kinase)IBA 12/2008
1	CytokinesIBA 12/2008
1	Epirubicin (Ellence)FDA LinkGeneric 01/2006
1	AnthracyclinesIBA 01/2006
1	LeptinIBA 09/2005
1	Glucose (Dextrose)FDA LinkGeneric 09/2005
1	ClayIBA 01/2002

Therapy/Procedure

1	Therapeutics 08/2013
1	Immunotherapy 08/2013